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No Title  of Publication Authors /Affiliation Date Reference
1 Gene × physical activity interactions in obesity: combined analysis of 111,421 individuals of European ancestry Ahmad S et al. ULUND 25 Jul 2013 PLoS Genet. 2013;9(7):e1003607. doi:

10.1371/journal.pgen.1003607. Epub 2013 Jul 25. PubMed PMID: 23935507

2 Clinical and genetic determinants of progression of type 2 diabetes: A DIRECT


Zhou K. et al.


01 Nov 2013 Diabetes Care. 2013 Nov 1. [Epub ahead of print] PubMed PMID: 24186880
3 Gene-environment and gene-treatment interactions in type 2 diabetes: progress, pitfalls, and prospects Franks P. pearson E. Florez J.  et al. ULUND UNIVDUN May 2013 Diabetes

Care. 2013 May;36(5):1413-21. doi: 10.2337/dc12-2211. Review. PubMed
PMID: 23613601

4 Weight loss independent association of TCF7L2 gene polymorphism with fasting blood glucose after Roux-en-Y Gastric Bypass in type 2 diabetes patients Rouskas K. et al. CHRU LILLE Submitted

Dec 2013

Surg Obes Relat Dis. Jul-Aug 2014;10(4):679-83. doi: 10.1016/j.soard.2013.12.016. Epub 2014 Jan 9.
5 Pancreatic islet enhancer clusters enriched in Type 2 diabetes risk-associated variants. Pasquali L et al. IDIBAPS,


Jan 2014 Nature Genetics 2014 Jan 12 [Epub ahead of print]. PMID: 24413736.
6 Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: rationale and design of the epidemiological studies within the IMI DIRECT consortium Koivula R. et al. ULUND Published 2014 Apr Diabetologia. 2014 Jun;57(6):1132-42. doi: 10.1007/s00125-014-3216-x. Epub 2014 Apr 4.
7 Innate biology versus lifestyle behaviour in the aetiology of obesity and type 2 diabetes: the GLACIER Study. Poveda A, Koivula RW, Ahmad S, Barroso I, Hallmans G, Johansson I, Renström F, Franks PW.ULUND 01 Dec 2015 Diabetologia. 2015 Dec 1. [Epub ahead of print] PubMed PMID: 26625858.
8 Statistical power considerations in genotype-based recall randomized controlled trials. Atabaki-Pasdar N, Ohlsson M, Shungin D, Kurbasic A, Ingelsson E, Pearson ER, Ali A, Franks PW.ULUND 2016 Nov 25 Sci Rep. 2016 Nov 25;6:37307. doi: 10.1038/srep37307 PMID:27886175
9 Causal inference in obesity research. Franks PW, Atabaki-Pasdar N. 2016 Dec 8 J Intern Med. 2017 Mar;281(3):222-232. doi: 10.1111/joim.12577. Epub 2016 Dec 8. PMID:27933671
10 Lifestyle and precision diabetes medicine: will genomics help optimise the prediction, prevention and treatment of type 2 diabetes through lifestyle therapy? Franks PW & Poveda A.


Epub Jan 2017 Diabetologia. 2017 May;60(5):784-792. doi: 10.1007/s00125-017-4207-5.

PMID: 28124081

11 Exposing the exposures in type 2 diabetes. Franks PW & McCarthy MI


2016Oct7 Science. 2016 Oct 7;354(6308):69-73. doi: 10.1126/science.aaf5094

PMID: 27846494

12 Putting the genome in context: gene-lifestyle interactions in type 2 diabetes. Franks PW & Pare G. 7May2016 Curr Diab Rep. 2016 Jul;16(7):57. doi: 10.1007/s11892-016-0758-y.
13 Sustained influence of metformin therapy on circulating glucagon-like peptide-1 levels in individuals with and without type 2 diabetes. Preiss D, Dawed A, Welsh P, Heggie A, Jones AG, Dekker J, Koivula R, et al DIRECT consortium group 2016 Dec 28 Diabetes Obes Metab. 2017 Mar;19(3):356-363. doi: 10.1111/dom.12826. Epub


PMID: 27862873.

14 Predicting glycated hemoglobin levels in the non-diabetic general population: Development and validation of the DIRECT-DETECT prediction model – a DIRECT study. Rauh SP, Heymans MW, Koopman AD, Nijpels G, Stehouwer CD, Thorand B, et al incl 2017 Feb10 PLoS One. 2017 Feb 10;12(2):e0171816. doi: 10.1371/journal.pone.0171816. eCollection 2017.

PMID: 28187151

15 Personalized medicine in diabetes: the role of ‘omics’ and biomarkers. Pearson ER. UNIVDUN June 2016 Diabet Med. 2016 Jun;33(6):712-7. doi: 10.1111/dme.13075
PMID: 26802434
16 Painting a new picture of personalised medicine for diabetes Mark McCarthy / UOXF 2017 Feb 7. Diabetologia. 2017 May;60(5):793-799. doi: 10.1007/s00125-017-4210-x

PMID: 28175964

17 Rates of glycaemic deterioration in a real-world population with type 2 diabetes. Donnelly LA, Zhou K, Doney ASF, Jennison C, Franks PW, Pearson ER. 2017 Dec 19. Diabetologia 2018 Mar;61(3):607-615. doi: 10.1007/s00125-017-4519-5. Epub 2017 Dec 19.
PMID: 29260253
18 Integrative network analysis highlights biological processes underlying GLP-1 stimulated insulin secretion: A DIRECT study Gudmundsdottir V, Pedersen HK, Allebrandt KV, Brorsson C, et al 2018 Jan 2 PLoS One. 2018 Jan 2;13(1):e0189886. doi: 10.1371/journal.pone.0189886. eCollection 2018.

PMID: 29293525

19 Metabolite ratios as potential biomarkers for type 2 diabetes: a DIRECT study. Molnos S, Wahl S, Haid M et al. 2018 Jan Diabetologia. 2018 Jan;61(1):117-129. doi: 10.1007/s00125-017-4436-7. Epub 2017 Oct 25.
PMID: 28936587
20 Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium. Koivula RW et al
for the IMI DIRECT Consortium.
2019 Jun 15 Diabetologia. 2019 Sep;62(9):1601-1615. doi: 10.1007/s00125-019-4906-1. Epub 2019 Jun 15.


PMID: 31203377

21 Type 2 diabetes: a multifaceted disease Ewan R. Pearson


2019 Jun 3 Diabetologia. 2019 Jul;62(7):1107-1112. doi: 10.1007/s00125-019-4909-y.

PMID: 31161345

22 Evidence-based prioritisation and enrichment of genes interacting with metformin in type 2 diabetes Adem Y. Dawed, Ashfaq Ali, Kaixin Zhou, Ewan R. Pearson, Paul W. Franks 2017 Aug 25. Diabetologia. 2017 Nov;60(11):2231-2239. doi: 10.1007/s00125-017-4404-2. Epub 2017 Aug 25

PMID: 28842730

23 The governance structure for data access in the DIRECT consortium: an innovative medicines initiative (IMI) project Harriet J. A. Teare, Federico de Masi, Karina Banasik, Anna Barnett, Sanna Herrgard, et al 2018 Sep 4


Life Sci Soc Policy. 2018 Sep 4;14(1):20. doi: 10.1186/s40504-018-0083-0


PMID: 30182269

24 Motivations for data sharing-views of research participants from four European countries: A DIRECT study.


Shah N, Coathup V, Teare H, Forgie I, Giordano GN, Hansen TH, Groeneveld L,

Et al

 2019 Jan 30.


Eur J Hum Genet. 2019 May;27(5):721-729. doi: 10.1038/s41431-019-0344-2. Epub 2019 Jan 30.


PMID: 30700834

25 Variation in the Plasma Membrane Monoamine Transporter (PMAT) (Encoded by SLC29A4) and Organic Cation Transporter 1 (OCT1) (Encoded by SLC22A1) and Gastrointestinal Intolerance to Metformin in Type 2 Diabetes: An IMI DIRECT Study. Dawed AY, Zhou K, van Leeuwen N, Mahajan A, Robertson N, Koivula R, Elders PJM, Rauh SP, Jones AG, et al 2019 Mar 18. Diabetes Care. 2019 Jun;42(6):1027-1033. doi: 10.2337/dc18-2182. Epub 2019 Mar 18.

PMID: 30885951


26 Sharing data for future research-engaging participants’ views about data governance beyond the original project: a DIRECT Study. Shah N, Coathup V, Teare H, Forgie I, Giordano GN, et al 2018 Sep 28. Genet Med. 2019 May;21(5):1131-1138. doi: 10.1038/s41436-018-0299-7. Epub 2018 Sep 28.

PMID: 30262927

27 The impact and correction of analysis delay and variability in storage temperature on the assessment of HbA1c from dried blood spots – an IMI DIRECT Study Nina Scherer et al
for the IMI DIRECT Consortium.
19 Jul 2019 International Journal of Proteomics & Bioinformatics, 2019; 4(1): 007-013.
28 Clinical profiles of post-load glucose subgroups and their association with glycaemic traits over time: a DIRECT Study Morgan Obura et al Re-submitted
29 Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration. Wilman HR, Parisinos CA, Atabaki-Pasdar N, Kelly M, Thomas EL, Neubauer S; IMI DIRECT Consortium, et al 2019 Jun 19. J Hepatol. 2019 Sep;71(3):594-602. doi: 10.1016/j.jhep.2019.05.032. Epub 2019 Jun 19.

PMID: 31226389

30 Aberrant intestinal microbiota in individuals with prediabetes. Allin KH, Tremaroli V, Caesar R, Jensen BAH, Damgaard MTF, Bahl MI,  IMI-DIRECT consortium, et al 2018 Apr Diabetologia. 2018 Apr;61(4):810-820. doi: 10.1007/s00125-018-4550-1. Epub 2018 Jan 29.

PMID: 29379988

31 Association of changes in inflammation with variation in glycaemia, insulin resistance and secretion based on the KORA study T. de Las Heras Gala, C. Herder, Femke Rutters, IMI DIRECT Consortium 2018 Oct 2 Diabetes Metab Res Rev. 2018 Nov;34(8):e3063. doi: 10.1002/dmrr.3063. Epub 2018 Oct 2. PMID: 30114727
32 The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study Koivula R, Atabaki-Pasdar N, Giordano GN et al. for the IMI DIRECT consortium. 30Jan2020 Diabetologia. 2020 Apr;63(4):744-756. doi: 10.1007/s00125-019-05083-6. Epub 2020 Jan 30.
PMID: 32002573
33 Multiomics signatures predictive of early diabetes remission following bariatric surgery: An IMI-DIRECT study Thomas, CE, Raverdy V, Pedersen HK, et al. for the IMI-DIRECT consortium Genome Biology  under review
34 Governance of academic research data under the GDPR—lessons from the UK Mourby M, Gowans H, Aidinlis S, Smith H, Kaye J 15th July 2019


International Data Privacy Law

35 Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts N. Atabaki-Pasdar , M. Ohlsson , A. Viñuela , F. Frau, H. Pomares-Millan et al June 2020 PLoS Med. 2020 Jun 19;17(6):e1003149. doi: 10.1371/journal.pmed.1003149. eCollection 2020 Jun.

PMID: 32559194

36 Dietary metabolite profiling brings new insight into the relationship between nutrition and metabolic risk: An IMI DIRECT study R. Eriksen, I. Garcia Perez, J M Posma, M. Haid, S. Sharma et al 4 Aug 2020 EBioMedicine. 2020 Aug;58:102932. doi: 10.1016/j.ebiom.2020.102932. Epub 2020 Aug 4.
PMID: 32763829
37 Genetics meets proteomics: perspectives for large population-based studies Karsten Suhre, Mark McCarthy, Jochen Schwenk 28 Aug 2020 Nat Rev Genet. 2020 Aug 28. doi: 10.1038/s41576-020-0268-2. Online ahead of print.
PMID: 32860016
38 Clinical profiles of post-load glucose subgroups and their association with glycaemic traits over time: an IMI-DIRECT study M Obura, J W J Beulens, R Slieker, A D M Koopman, T Hoekstra, G Nijpels,  et al 17 Oct 2020 Diabet Med. 2020 Oct 17; e14428. doi: 10.1111/dme.14428.
PMID: 33067862
39 Genome-Wide Association Analysis of Pancreatic Beta Cell Glucose Sensitivity Harshal A Deshmukh, Anne Lundager Madsen, Ana Viñuela, et al 1 Jan 2021 J Clin Endocrinol Metab. 2020 Sep 18;dgaa653. doi: 10.1210/clinem/dgaa653.
PMID: 32944759
40 The impact of sex on gene expression across human tissues


The GTEx Consortium atlas of genetic regulatory effects across human tissues


Cell type-specific genetic regulation of gene expression across human tissues

Ana Vinuela,

Andrew Brown,

Manolis Dermitzakis in the GTEx consortium

11 Sep 2020 Three GTEx papers accepted by Science. Ana Vinuela et al.

PMID: 32913072; DOI: 10.1126/science.aba3066

PMID: 32913098; DOI: 10.1126/science.aaz1776

PMID: 32913075; DOI: 10.1126/science.aaz8528

41 A reference map of potential determinants for the human serum metabolome. Bar N, Korem T, Weissbrod O, Zeevi D, Rothschild D, Leviatan S, Kosower N, Lotan-Pompan M, Weinberger A, Le Roy CI, Menni C, Visconti A, Falchi M, Spector TD; IMI DIRECT consortium, Adamski J, Franks PW, Pedersen O, Segal E. Nov 20 Nature. 2020 Dec;588(7836):135-140.
doi: 10.1038/s41586-020-2896-2.
Epub 2020 Nov 11.PMID: 33177712(External paper)
42 Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study Valborg Gudmundsdottir, Helle Krogh Pedersen, Gianluca Mazzoni, Kristine H. Allin,et al 1 Dec 20 Genome Med. 2020
Dec 1;12(1):109. doi: 10.1186/s13073-020-00806-6.
PMID: 33261667
43 Post-load glucose subgroups and associated metabolic traits 1 in individuals with type 2 diabetes: an IMI-DIRECT study. Morgan Obura, Joline Beulens, Roderick Slieker, Anitra  Koopman et al 30Nov20 PLoS One. 2020
Nov 30;15(11):e0242360. doi: 10.1371/journal.pone.0242360. eCollection 2020.PMID: 33253307
44 Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: an IMI DIRECT study Caroline Brorsson; Agata Wesolowska-Andersen; Roberto Bizzotto; Andrea Mari; Andrea Tura; Robert Koivula; Anubha Mahajan; Ana Vinuela Dec 20 Cell Metabolism
45 Processes Underlying Glycaemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study Roberto Bizzotto, Christopher Jennison, Angus G Jones, Azra Kurbasic , Andrea Tura, Gwen Kennedy, et al for the DIRECT comnsortium 2020 Dec 15 Diabetes Care
2021 Feb; 44(2):511-518.
doi: 10.2337/dc20-1567.
EpubPMID: 33323478